The Ley Group
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NEWS
Steve Ley is awarded the 2009 Tetrahedron Prize

WHIFFEN COMMUNICATIONS (Group amd alumni only)
May 2009

LATEST PUBLICATIONS
Pd-EnCat TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-substituted Acetylenes via Microwave Assisted Sonogashira type Reactions
J. Sedelmeier, S.V. Ley, H. Lange and I.R. Baxendale, Eur. J. Org. Chem., 2009, 4412.

Enantioselective Synthesis of the Lyngbouilloside Macrolactone Core
D. Webb, A. van den Heuval, M. Kögl and S.V. Ley, Synlett, 2009, 14, 2320.

Cancer, Chemistry, and the Cell: Molecules that Interact with the Neurotensin Receptors
R.M. Myers, J.W. Shearman, M.O. Kitching, A. Ramos-Montoya, D.E. Neal, S.V. Ley, ACS Chem. Biol., 2009, 4, 503.

Development of Fluorination Methods using Continuous-Flow Microreactors

M. Baumann, I.R. Baxendale, L.J. Martin and S.V. Ley, Tetrahedron, 2009, 65, 6611.

Total Synthesis of the Potent Antifungal Agents Bengazole C and E

A. Enríquez-Garcia and S.V. Ley, Coll. Czech. Chem. Comm., 2009, 74, 887.


LAB LETTERS
Problems Set
by Dr David France (11 Nov 2009)
Synthesis of Chlorosulfolipids by Daniel Salinger (11 Sept 2009)
C20-Diterpenoid Alkaloid Anthriscifolmine D
by Sarah Harding (21 Aug 2009)
Exercises on
Guanacastepene E by Dr Georg Wuitschik (19 June 2009)
Some Stereoelectronic Considerations
by
Dr Matt O’Brien (15 May 2009)
Friday 13th Synthesis Discussion
by Dr Colin Pearson (13 February 2009)
Phosphorus & Sulfur Blind Lab Letter
byJames Shearman (January 2009)
Movember's Lab Letter
by Jane Jin (26 November 2008)
October's Lab Letter
by Alex Oelke (31 October 2008)
July Synthesis Discussion (Cortistatin A)
by Dr Ross Denton (4 July 2008)

May Questions by Dr Antoine Francais (16 May 2008)
April Exercises by Dr Alvaro Enriquez (11 April 2008)
Leap Year Puzzle by Dr Christoph Tzschucke (29 Feb 2008)
New Year Exercises
by Alejandro Dieguez-Vazquez (25 Jan 2008)

LINKS
Not Voodoo by Alison Frontier
Natural and Unnatural Amino Acid Abbreviations MEROPS Peptidase Database

The artwork for this year's Research Synopsis (and our group web page) has been created by one of our post-docs.
'The Great Work’ by Matthew O'Brien acrylic on canvas board, 2008 © Matthew O'Brien 2008

The painting is an abstract depiction of azadirachtin, whose synthesis was recently completed by the Ley group. The culmination of over 2 decades of work, the project represents a herculean struggle which was only made possible by the great physical and intellectual efforts of those involved. As the painting attempts to portray, the complex and challenging nature of this molecule (and others) requires and inspires a high degree of creativity and imagination in the mind of the chemist.

Updated on Thursday 26 October 2009